Dr. John Dolittle (Robert Downey Jr.) is a veterinarian who has the ability to communicate with animals. After his wife, Lily (Kasia Smutniak) dies at sea, Dolittle becomes a recluse, tending to only animals and refusing to contact or assist with other humans. One day, a boy named Tommy Stubbins (Harry Collett) accidentally shoots and wounds a squirrel named Kevin (Craig Robinson) and is guided to Dolittle for help by a macaw named Polynesia (Emma Thompson).
Meanwhile, Queen Victoria (Jessie Buckley) sends a girl named Lady Rose (Carmel Laniado) with a message, ordering Dolittle to come in order to try to cure the queen of a deadly sickness. After being persuaded by Polynesia that he has to start trying to reconnect with fellow humans, Dolittle finally decides to go. Upon reaching her, he finds that the Queen has been poisoned by a type of nightshade that was added to her tea. To be cured, she must eat a fruit from a far away land.
Starring: Robert Downey Jr., Antonio Banderas, Michael Sheen, Emma Thompson, Rami Malek, John Cena, Kumail Nanjiani, Octavia Spencer, Tom Holland, Craig Robinson, Ralph Fiennes, Selena Gomez, Marion Cotillard,
